I'll start with a list of links I think are important to understanding DHA.
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IMHO, If
you just read one thing about DHA, Leukodystrophy and
peroxisome disorders read this
This is the web site of the parents of Ian Harris, a boy with IRD. It primarily provides a parental perspective. Ian's father, John Harris, also maintains an International email list for parents and caregivers of children with peroxisome biogenesis disorders. Given the rare context of these disorders, the email list provides an important means of information sharing and mutual support among the parents and care givers.
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Read about DHA and peroxidation on this site
I mean it. Get back to me after you read about peroxidation on this site.
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In
Manuela Martinez's, M.D. article "Peroxisomal
disorders and their treatment"
IMO, she makes it very clear that DHA is a food supplement, however it must be administered under medical supervision including frequent blood tests. The blood levels of all lipids must be monitored when DHA is used to treat or prevent disease.
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Comment
in: Neurology. 1998 Jul;51(1):5-7.
Title: Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disorders"From a clinical viewpoint, most patients showed improvement in vision, liver function, muscle tone, and social contact"
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What the heck is a generalized peroxisomal
disorder
Peroxisomal disorders are a group of congenital diseases characterized by the absence of normal peroxisomes in the cells of the body. Peroxisomes are organelles within a cell that contain enzymes responsible for critical cellular processes, including oxidation of fatty acids, biosynthesis of membrane phospholipids (plasmalogens), cholesterol, and bile acids, conversion of amino acids into glucose, reduction of hydrogen peroxide by catalase, and prevention of excess synthesis of oxalate
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MRI evidence that docosahexaenoic acid ethyl ester
improves myelinization in generalized peroxisomal
disorders.
Early initiation of DHA therapy is thus strongly recommended in patients with generalized peroxisomal disorders.
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Peroxisome.org
This site was created and is maintained by the laboratory of Stephen J. Gould at The Johns Hopkins University School of Medicine. Whether you are a scientist working on the peroxisome in need of a good reference site, a physician seeing a patient with a potential peroxisomal disorder, or a patient or layperson wanting to know more about the peroxisome and its associated disorders in simple, less scientific terms, this site will be able to provide information and further references.
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Adrenoleukodystrophy & Lorenzo's Oil
Once you get to this page scroll down the left hand side and select Lorenzo’s Oil or Glycerol Trioleate Oil. In addition to DHA Joey takes 3 tablespoons of glycerol trioleate oil (GTO). When I get the chance i'll spell out how we arrived at Joey's present treatment. It took about 6 years to get it like it has been for the last six years.
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THE PBD PROJECT
PBD stands for Peroxisomal Biogenesis Disorders. The PBD project is essentially a charity group which has been set up to raise funds to support existing research and future research into Peroxisomal Biogenesis Disorders.
- DocosaHexaenoic Acid References
- Interesting alternative view
- Funding recieved from the Cystic Fibrosis Foundation to study infant formula supplemented with DHA in newborns diagnosed with CF.
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Study in Mouse Model Suggests Dietary DHA Could
Protect Against Alzheimer's
"This study is significant because it shows that DHA added to the diet altered the processing of the amyloid precursor protein and the accumulation of its toxic amyloid protein metabolite that is widely believed to cause Alzheimer's. These and other beneficial results were observed even when the diets were changed late in life," said Dr. Greg Cole, the study's lead investigator. Dr. Cole is the Associate Director for Geriatric Research at the VA Greater Los Angeles and Professor of Medicine and Neurology at UCLA."
